Altered cyclin D1 genotype distribution in human sporadic pituitary adenomas


Gazioglu N. , ERENSOY N., Kadioglu P. , SAYITIOGLU M. A. , ERSOY I. H. , HATIMAZ O., ...Daha Fazla

MEDICAL SCIENCE MONITOR, cilt.13, 2007 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 13 Konu: 10
  • Basım Tarihi: 2007
  • Dergi Adı: MEDICAL SCIENCE MONITOR

Özet

Background: The cyclin D1 gene (CCND1) is a proto-oncogene playing a critical role in the transition through the G1 ot the S phase of the cell cyle and is overexpressed in many tumors. G870A plymorphism at the exon4/intron4 splicing region of the CCND1 gene may play a role in pituitary tumorigenesis and invasiveness. The objective of this study was to examine CCND1 polymorphism i patients with different types sporadic pituitary adenomas.