Telomeric DNA: Marker for human prostate cancer development?


ÖZEN M. , Imam S., Datar R., Multani A., Narayanan A., Chung L., ...Daha Fazla

PROSTATE, cilt.36, ss.264-271, 1998 (SCI İndekslerine Giren Dergi) identifier identifier identifier identifier

  • Cilt numarası: 36 Konu: 4
  • Basım Tarihi: 1998
  • Dergi Adı: PROSTATE
  • Sayfa Sayıları: ss.264-271

Özet

BACKGROUND. Telomeres that protect chromosomes at both ends are shortened with each somatic cell division through replication-dependent sequence loss at DNA termini. The chromosomes with shortened telomeres tend to become unstable, leading to cell death. Due largely to reactivation/upregulation of telomerase, a ribonucleoprotein that adds nucleotide sequences onto chromosome ends, cancer cells become immortal and neoplastically transformed.