The effect of high mobility group box-1 protein on cerebral edema, blood-brain barrier, oxidative stress and apoptosis in an experimental traumatic brain injury model


Evran S., ÇALIŞ F., Akkaya E., Baran O., Cevik S., Katar S., et al.

BRAIN RESEARCH BULLETIN, cilt.154, ss.68-80, 2020 (SCI İndekslerine Giren Dergi)

Özet

Traumatic brain injury (TBI) is one of the important reason of morbidity and mortality. While the primary injury due to mechanical impact is unavoidable, the secondary injury which is formed as a result of primary injury and thought to occur due to neurointlammation in the forefront can be prevented and by this way mortality and morbidity can be reduced. High mobility group box-1 (HMGB1) is a protein that triggers the neuroinflammatory process by being released from the nucleus of necrotic tissues after primary injury.