Collagen ultrastructure and TGF-beta 1 expression preserved with aminoguanidine during wound healing in diabetic rats


Yavuz D., Tugtepe H., Cetinel S., Uyar S., Kaya H., Haklar G., ...Daha Fazla

ENDOCRINE RESEARCH, cilt.31, ss.229-243, 2005 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 31 Konu: 3
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1080/07435800500373140
  • Dergi Adı: ENDOCRINE RESEARCH
  • Sayfa Sayıları: ss.229-243

Özet

Advanced glycoxidation end products have been implicated in delayed diabetic wound healing. In this study, we evaluated the effects of aminoguanidine, which is an advanced glycation and nitric oxide ( NO) synthase inhibitor, on extracellular matrix protein expression, collagen configuration, and nitrite/nitrate levels in wounds of diabetic rats.