Lack of association between the IL1A gene (-889) polymorphism and outcome after head injury


Tanriverdi T., Uzan M., Sanus G., Baykara O., Is M., Ozkara C. , et al.

SURGICAL NEUROLOGY, cilt.65, ss.7-10, 2006 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 65 Konu: 1
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1016/j.surneu.2005.05.024
  • Dergi Adı: SURGICAL NEUROLOGY
  • Sayfa Sayısı: ss.7-10

Özet

Background: Interleukin (IL) I is a proinflammatory cytokine that has been identified as an important mediator of neurodegeneration induced by ischemia or traumatic brain injury. Accumulating evidence to date has suggested that the major cytokine contributing to neurodegeneration after head injury is IL-1 beta rather than IL-1 alpha; however, there is no sufficient data regarding IL-1 alpha in literature, and there may be an association between IL1A gene polymorphism and outcome after head injury.