Synthesis and biological potentials of dioxomolybdenum(VI) complexes with ONS and ONN chelating thiosemicarbazones: DNA-binding, antioxidant and enzyme inhibition studies


Eglence-Bakir S., Sahin M. , Zahoor M., Dilmen-Portakal E., ÜLKÜSEVEN B.

POLYHEDRON, cilt.190, 2020 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 190
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.poly.2020.114754
  • Dergi Adı: POLYHEDRON

Özet

In this study dioxomolybdenum (VI) complexes of 5-methoxysalicylidene N- or S-alkyl substituted thiosemicarbazones {where alkyl is N-methyl (L1), N-octyl (L2), S-methyl (L3) or S-octyl (L4)} were synthesized, characterized by different spectroscopic techniques (UV, IR, H-1 NMR). The structure of the complex with S-methyl-substituted thiosemicarbazone (complex 3) was also determined by X-ray diffraction method. The compounds were evaluated for their antibacterial, antioxidant, anticholinesterase, antidiabetic, and DNA interaction potentials. K. pneumonia was more potently inhibited by ligand L3 (29 +/- 0.025 mm zone of inhibition) while E. coli and S. typhi by complex 2 with zone of inhibition of about 28 +/- 0.082 and 26 +/- 0.245 mm respectively. Complex 2 more potently scavenged DPPH free radical with IC50 of 231 mu g/mL while ABTS by ligand L1 (IC50 = 350 mu g/mL). Complex 4 with S-octyl was found to have high percent inhibition of acetylcholinesterase with IC50 of 104 mu g/mL. Complex 4 strongly inhibited alpha-amylase with an IC50 value of 153 mg/ml while ligand L4 with IC50 value of 285 mg/ml was more potent inhibitor of alpha-glucosidase. DNA interaction studies revealed the noncovalent interaction of these compounds with DNA. Highest binding constant among these compounds was recorded for ligand L2 with blue shifts and hyperchromism while lowest for L3. (C) 2020 Elsevier Ltd. All rights reserved.