The expression of astroglial glutamate transporters in patients with focal cortical dysplasia: an immunohistochemical study


Ulu M. O. , Tanriverdi T. , Oz B. , Biceroglu H., Isler C., ERASLAN B. S. , ...Daha Fazla

ACTA NEUROCHIRURGICA, cilt.152, ss.845-853, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 152 Konu: 5
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1007/s00701-009-0548-2
  • Dergi Adı: ACTA NEUROCHIRURGICA
  • Sayfa Sayıları: ss.845-853

Özet

An abnormal increase in the extracellular glutamate is thought to play a crucial role in the initiation, spread, and maintenance of seizure activity.In normal conditions, the majority of this excess glutamate is cleared via glial glutamate transporters (EAAT-1 and EAAT-2). We aimed to examine the immunohistochemical expression of these transporters in the dysplastic tissues of patients with focal cortical dysplasia (FCD).