Cerebellar volume loss in radiologically isolated syndrome

George I. C. , El Mendili M. M. , Inglese M., Azevedo C. J. , Kantarci O., Lebrun C., ...More

Multiple Sclerosis Journal, vol.27, no.1, pp.130-133, 2021 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 1
  • Publication Date: 2021
  • Doi Number: 10.1177/1352458519887346
  • Title of Journal : Multiple Sclerosis Journal
  • Page Numbers: pp.130-133


© The Author(s), 2019.Radiologically isolated syndrome (RIS), in which asymptomatic demyelinating-appearing lesions are detected incidentally on MRI, can be a pre-clinical form of multiple sclerosis (MS). In this study, we measured cerebellar volumes on 3D T1-weighted 3T MR images in 21 individuals with RIS and 38 age- and sex-matched healthy controls (HC). Normalized cerebellar white matter volume and the anterior cerebellar gray matter volume were significantly decreased in RIS compared to HC (p = 0.003 and p = 0.005, respectively). Our findings support reports of regional brain atrophy in RIS prior to the development of a seminal attack related to inflammatory demyelination.